This can be incredibly challenging in genomics. Focus on what you can understand easily and what you can learn with a little bit of effort. Do NOT attempt to understand all the pieces in one sitting. Reading papers easily requires training and practice. Treat it like preparing for an athletic event or a concert. Start slow and be persistent.
What should I do?
Answer all of the following questions. Please type your answers in the space below each question. Your answers are due BEFORE the class discussion. The remaining 5 points will come from your engaged participation in the class conversation.

Q1: From the Nature Comment: What are some advantages and concerns with using genetic data to predict disease risk?

Q2: Do a small (<10 minute) amount of research. What is a polygenic risk score? How are they calculated?

Q3: The second paper is currently housed in medRxiv. This is a database for “pre-publication” data that has not yet been peer reviewed. Individuals can provide comments at medRxiv that might improve the paper before publication. Reflect on your understanding on the publication process. What are the advantages and disadvantages of pre-publication review?

Q4: Based on the data provided, and with consideration of financial and ethical implications, would you recommend Genome Sequencing or a Targeted Gene Panel to families with young children?

Q5: What questions or criticisms do you have of the medRxiv paper? What data or additional context would you want to see before final publication?